Lab publications (click on PDF to download file)

2010 - today

Laterreur, N. and Wellinger, RJ. La télomérase de la levure subit une cure de rajeunissement. Médecine/Sciences, 2017, 33(12): 1051-1054.  doi: 10.1051/medscié20173312011. 


Guintini, L., Tremblay, M., Toussaint, M., D’Amours, A., Wellinger, RE., Wellinger, RJ. and Conconi, A. Repair of UV-induced DNA lesions in natural Saccharomyces cerevisiae telomeres is moderated by Sir2 and Sir3, and inhibited by yKu–Sir4 interaction. Nucleic Acids Research, 2017 (1) doi: 10.1093/nar/gkx123.


Vasianovich Y and Wellinger RJ. Life and Death of Yeast Telomerase RNA. Journal of Molecular Biology. 2017 Jan 20. pii: S0022-2836(17)30041-4. doi: 10.1016/j.jmb.2017.01.013


Larcher MV, Pasquier E, MacDonald RS, Wellinger RJ. Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends. 

PLoS Genet. 2016 Dec 8;12(12):e1006479. doi: 10.1371


Lemieux B, Laterreur N, Perederina A, Noël JF, Dubois ML, Krasilnikov AS, Wellinger RJ. Active Yeast Telomerase Shares Subunits with Ribonucleoproteins RNase P and RNase MRP. Cell. 2016 May 4.


Mersaoui S., Gravel S., Karpov V., Prud’Homme C., Lisby M. and Wellinger R.J. DNA damage checkpoint adaptation genes are required for division of cells harbouring eroded telomeres. Microbial Cell. 2015. Sept; 2: 394-405


Bajon E, Laterreur N, Wellinger RJ. A Single Templating RNA in Yeast Telomerase. Cell Rep. 2015 Jul 21;12(3):441-8.


Lemieux B, Blanchette M, Monette A, Mouland AJ, Wellinger RJ, Chabot B. A Function for the hnRNP A1/A2 Proteins in Transcription Elongation. PLoS One. 2015 May 26;10(5):e0126654.


Wellinger RJ. Turning telomerase into a Jekyll and Hyde case? Cancer Discov. 2015 Jan;5(1):19-21. 


Wellinger RJ. In the end, what's the problem? Mol Cell. 2014 Mar 20;53(6):855-6. 


Laterreur N, Eschbach SH, Lafontaine DA, Wellinger RJ. A new telomerase RNA element that is critical for telomere elongation. Nucleic Acids Res. 2013 Jun 19.


Balestrini A, Ristic D, Dionne I, Liu XZ, Wyman C, Wellinger RJ, Petrini JH. The Ku heterodimer and the metabolism of single-ended DNA double-strand breaks. Cell Rep. 2013 Jun 27;3(6):2033-45. doi: 10.1016/j.celrep.2013.05.026. Epub 2013 Jun 13.


Dionne I, Larose S, Dandjinou AT, Abou Elela S, Wellinger RJ. Cell cycle-dependent transcription factors control the expression of yeast telomerase RNA. RNA 2013 Jul;19(7):992-1002.


Gallardo F, Laterreur N, Wellinger RJ, Chartrand P. Telomerase caught in the act: united we stand, divided we fall. RNA Biol. 2012 Sep;9(9):1139-43.


Wellinger RJ, Zakian VA. Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end. Genetics. 2012 Aug;191(4):1073-105. doi: 10.1534/genetics.111.137851.


Noël JF, Wellinger RJ. Exposing secrets of telomere-telomerase encounters. Cell. 2012 Aug 3;150(3):453-4. doi: 10.1016/j.cell.2012.07.015.


Erratum in Cell. 2012 Aug 31;150(5):1082.

Comment on Cell. 2012 Aug 3;150(3):481-94.


Londoño-Vallejo JA, Wellinger RJ. Telomeres and telomerase dance to the rhythm of the cell cycle. Biochem Sci. 2012 Sep;37(9):391-9. doi: 10.1016/j.tibs.2012.05.004.


Noël JF, Larose S, Abou Elela S, Wellinger RJ. Budding yeast telomerase RNA transcription termination is dictated by the Nrd1/Nab3 non-coding RNA termination pathway. Nucleic Acids Res. 2012 Jul;40(12):5625-36. doi: 10.1093/nar/gks200.


Gallardo F, Laterreur N, Cusanelli E, Ouenzar F, Querido E, Wellinger RJ & Chartrand P. Live cell imaging of telomerase RNA dynamics reveals cell cycle-dependent clustering of telomerase at elongating telomeres. Mol Cell. 2011 Dec 9;44(5):819-27. doi: 10.1016/j.molcel.2011.09.020.


Comment in Mol Cell. 2011 Dec 9;44(5):685-6.


Pelloux J, Tremblay M, Wellinger RJ, Conconi A. UV-induced DNA damage and DNA repair in ribosomal genes chromatin. Methods Mol Biol. 2012;809:303-20. doi: 10.1007/978-1-61779-376-9_21.

Parenteau J, Durand M, Morin G, Gagnon J, Lucier JF, Wellinger RJ, Chabot B, Elela SA. Introns within ribosomal protein genes regulate the production and function of yeast ribosomes. Cell. 2011 Oct 14;147(2):320-31. doi: 10.1016/j.cell.2011.08.044.


Bah A, Gilson E, Wellinger RJ. Telomerase is required to protect chromosomes with vertebrate-type T2AG3 3' ends in Saccharomyces cerevisiae. J Biol Chem. 2011 Aug 5;286(31):27132-8. doi: 10.1074/jbc.M111.220186.


Prinos P, Garneau D, Lucier JF, Gendron D, Couture S, Boivin M, Brosseau JP, Lapointe E, Thibault P, Durand M, Tremblay K, Gervais-Bird J, Nwilati H, Klinck R, Chabot B, Perreault JP, Wellinger RJ, Elela SA. Alternative splicing of SYK regulates mitosis and cell survival. Nat Struct Mol Biol. 2011 Jun;18(6):673-9. doi: 10.1038/nsmb.2040


Leduc F, Faucher D, Bikond Nkoma G, Grégoire MC, Arguin M, Wellinger RJ, Boissonneault G. Genome-wide mapping of DNA strand breaks. PLoS One. 2011 Feb 25;6(2):e17353. doi: 10.1371/journal.pone.0017353


Noël JF, Wellinger RJ. Abrupt telomere losses and reduced end-resection can explain accelerated senescence of Smc5/6 mutants lacking telomerase. DNA Repair (Amst). 2011 Mar 7;10(3):271-82. doi: 10.1016/j.dnarep.2010.11.010.


Faucher D, Wellinger RJ. Methylated H3K4, a transcription-associated histone modification, is involved in the DNA damage response pathway. PLoS Genet. 2010 Aug 26;6(8). pii: e1001082. doi: 10.1371/journal.pgen.1001082


Vodenicharov MD, Laterreur N, Wellinger RJ. Telomere capping in non-dividing yeast cells requires Yku and Rap1. EMBO J. 2010 Sep 1;29(17):3007-19. doi: 10.1038/emboj.2010.155


Wellinger RJ. When the caps fall off: responses to telomere uncapping in yeast. FEBS Lett. 2010 Sep 10;584(17):3734-40. doi: 10.1016/j.febslet.2010.06.031


Toussaint M, Wellinger RJ, Conconi A. Differential participation of homologous recombination and nucleotide excision repair in yeast survival to ultraviolet light radiation. Mutat Res. 2010 Apr 30;698(1-2):52-9. doi: 10.1016/j.mrgentox.2010.03.013.


2000 - 2009

Wellinger RJ. The CST complex and telomere maintenance: the exception becomes the rule. Mol Cell. 2009 Oct 23;36(2):168-9. doi: 10.1016/j.molcel.2009.10.001.


Gunisova S, Elboher E, Nosek J, Gorkovoy V, Brown Y, Lucier JF, Laterreur N, Wellinger RJ, Tzfati Y, Tomaska L. Identification and comparative analysis of telomerase RNAs from Candida species reveal conservation of functional elements. RNA. 2009 Apr;15(4):546-59. doi: 10.1261/rna.1194009.


Knecht H, Sawan B, Lichtensztejn D, Lemieux B, Wellinger RJ, Mai S. The 3D nuclear organization of telomeres marks the transition from Hodgkin to Reed-Sternberg cells. Leukemia. 2009 Mar;23(3):565-73. doi: 10.1038/leu.2008.314. 


Venables JP, Klinck R, Bramard A, Inkel L, Dufresne-Martin G, Koh C, Gervais-Bird J, Lapointe E, Froehlich U, Durand M, Gendron D, Brosseau JP, Thibault P, Lucier JF, Tremblay K, Prinos P, Wellinger RJ, Chabot B, Rancourt C, Elela SA. Identification of alternative splicing markers for breast cancer. Cancer Res. 2008 Nov 15;68(22):9525-31. doi: 10.1158/0008-5472.CAN-08-1769.


Parenteau J, Durand M, Véronneau S, Lacombe AA, Morin G, Guérin V, Cecez B, Gervais-Bird J, Koh CS, Brunelle D, Wellinger RJ, Chabot B, Abou Elela S. Deletion of many yeast introns reveals a minority of genes that require splicing for function. Mol Biol Cell. 2008 May;19(5):1932-41. doi: 10.1091/mbc.E07-12-1254.


Gallardo F, Olivier C, Dandjinou AT, Wellinger RJ, Chartrand P. TLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres. EMBO J. 2008 Mar 5;27(5):748-57. doi: 10.1038/emboj.2008.21.


Vodenicharov MD, Wellinger RJ. The cell division cycle puts up with unprotected telomeres: cell cycle regulated telomere uncapping as a means to achieve telomere homeostasis. Cell Cycle. 2007 May 15;6(10):1161-7.


Larose S, Laterreur N, Ghazal G, Gagnon J, Wellinger RJ, Elela SA . RNase III-dependent regulation of yeast telomerase. J Biol Chem. 2007 Feb 16;282(7):4373-81.


Vodenicharov MD, Wellinger RJ. DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase. Mol Cell. 2006 Oct 6;24(1):127-37.


Larrivée M, Wellinger RJ. Telomerase- and capping-independent yeast survivors with alternate telomere states. Nat Cell Biol. 2006 Jul;8(7):741-7. 


Toussaint M, Levasseur G, Gervais-Bird J, Wellinger RJ, Elela SA, Conconi A. A high-throughput method to measure the sensitivity of yeast cells to genotoxic agents in liquid cultures. Mutat Res. 2006 Jul 14;606(1-2):92-105.


Pandita RK, Sharma GG, Laszlo A, Hopkins KM, Davey S, Chakhparonian M, Gupta A, Wellinger RJ, Zhang J, Powell SN, Roti Roti JL, Lieberman HB, Pandita TK. Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair. Mol Cell Biol. 2006 Mar;26(5):1850-64.


Berthiau AS, Yankulov K, Bah A, Revardel E, Luciano P, Wellinger RJ, Géli V, Gilson E. Subtelomeric proteins negatively regulate telomere elongation in budding yeast. EMBO J. 2006 Feb 22;25(4):846-56.


Chakhparonian M, Faucher D, Wellinger RJ . A mutation in yeast Tel1p that causes differential effects on the DNA damage checkpoint and telomere maintenance. Curr Genet. 2005 Nov;48(5):310-22.


LeBel C, Larrivée M, Bah A, Laterreur N, Lévesque N, Wellinger RJ. Assessing telomeric phenotypes. Methods Mol Biol. 2006;313:265-316.

LeBel Assess Telo Pheno.pdf

Dandjinou AT, Larrivée M, Wellinger RE, Wellinger RJ. Two-dimensional agarose gel analysis of DNA replication intermediates. Methods Mol Biol. 2006;313:193-208.

Dandjinou 2D gels.pdf

Parenteau J, Klinck R, Good L, Langel U, Wellinger RJ, Elela SA. Free uptake of cell-penetrating peptides by fission yeast. FEBS Lett. 2005 Aug 29;579(21):4873-8.


LeBel C, Wellinger RJ. Telomeres: what's new at your end? J Cell Sci. 2005 Jul 1; 118(Pt 13):2785-8.


Toussaint M, Dionne I, Wellinger RJ. Limited TTP supply affects telomere length regulation in a telomerase-independent fashion. Nucleic Acids Res. 2005 Jan 28;33(2):704-13.


Patry C, Lemieux B, Wellinger RJ, Chabot B. Targeting heterogeneous nuclear ribonucleoparticule A1 and A2 proteins by RNA interference promotes cell death in transformed but not in normal mouse cell lines.  Mol Cancer Ther. 2004 Oct;3(10):1193-9.


Dandjinou AT, Lévesque N, Larose S, Lucier JF, Abou Elela S, Wellinger RJ. A phylogenetically based secondary structure for the yeast telomerase RNA. Curr Biol. 2004 Jul 13;14(13):1148-58.


Larrivée M, LeBel C, Wellinger RJ. The generation of proper constitutive G-tails on yeast telomeres is dependent on the MRX complex. Genes Dev. 2004 Jun 15;18(12):1391-6.


Bah A, Bachand F, Clair E, Autexier C, Wellinger RJ. Humanized telomeres and an attempt to express a functional human telomerase in yeast. Nucleic Acids Res. 2004 Mar 26;32(6):1917-27.


LeBel C, Wellinger RJ.  [The structures at the termini of chromosomes: what is there hidden under the cap?]. Med Sci (Paris). 2004 Feb;20(2):207-12. [Article in French]


Sharma GG, Hwang KK, Pandita RK, Gupta A, Dhar S, Parenteau J, Agarwal M, Worman HJ, Wellinger RJ, Pandita TK. Human heterochromatin protein 1 isoforms HP1 (Hsalpha) and HP1 (Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation. Mol Cell Biol. 2003 Nov;23(22):8363-76.


Chakhparonian M, Wellinger RJ. Telomere maintenance and DNA replication: how closely are these two connected? Trends Genet. 2003 Aug;19(8):439-46.


Conconi A, Wellinger RJ. A new link for a linker histone. Mol Cell. 2003 Jun;11(6):1421-3. 

Comment on Mol Cell. 2003 Jun;11(6):1685-92. 


Parenteau J, Wellinger RJ. Differential processing of leading- and lagging-strand ends at Saccharomyces cerevisiae telomeres revealed by the absence of Rad27p nuclease. Genetics. 2002 Dec;162(4):1583-94.


Gravel S, Wellinger RJ. Maintenance of double-stranded telomeric repeats as the critical determinant for cell viability in yeast cells lacking Ku. Mol Cell Biol. 2002 Apr;22(7):2182-93.


Dhar S, Squire JA, Hande MP, Wellinger RJ, Pandita TK. Inactivation of 14-3-3sigma influences telomere behavior and ionizing radiation-induced chromosomal instability. Mol Cell Biol. 2000 Oct;20(20):7764-72.


Driller L, Wellinger RJ, Larrivee M, Kremmer E, Jaklin S, Feldmann HM. A short C-terminal domain of Yku70p is essential for telomere maintenance. J Biol Chem. 2000 Aug 11;275(32):24921-7.


Adams Martin A, Dionne I, Wellinger RJ, Holm C. The function of DNA polymerase alpha at telomeric G  tails is important for telomere homeostasis. Mol Cell Biol. 2000 Feb;20(3):786-96.


1990 - 1999

Bouffard P, Brière F, Wellinger RJ, Boire G. Identification of ribonucleoprotein (RNP)-specific protein interactions using a yeast RNP interaction trap assay (RITA). Biotechniques. 1999 Oct;27(4):790-6.

Parenteau J, Wellinger RJ. Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27. Mol Cell Biol. 1999 Jun;19(6):4143-52.


Dandjinou AT, Dionne I, Gravel S, LeBel C, Parenteau J, Wellinger RJ. Cytological and functional aspects of telomere maintenance. Histol Histopathol. 1999 Apr;14(2):517-24.

Dionne I, Wellinger RJ. Processing of telomeric DNA ends requires the passage of a replication fork. Nucleic Acids Res. 1998 Dec 1;26(23):5365-71.


LaBranche H, Dupuis S, Ben-David Y, Bani MR, Wellinger RJ, Chabot B. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat Genet. 1998 Jun;19(2):199-202.

Comment in Nat Genet. 1998 Jun;19(2):103-4.


Gravel S, Larrivée M, Labrecque P, Wellinger RJ. Yeast Ku as a regulator of chromosomal DNA end structure. Science. 1998 May 1;280(5364):741-4.


McElligott R, Wellinger RJ. The terminal DNA structure of mammalian chromosomes. EMBO J. 1997 Jun 16;16(12):3705-14.


Wellinger RJ, Sen D. The DNA structures at the ends of eukaryotic chromosomes. Eur J Cancer. 1997 Apr;33(5):735-49.


Dionne I, Wellinger RJ. Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13902-7.


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